I think so? I have long stretches of thick black plastic already in use for areas where I want to kill everything. I opened one of those patches already this spring to throw some shade-tolerant wildflower seed there, in the shadow of the now-empty crack house.

Part of the problem is that I intend to go full prairie/native plants for much of the yard, and I enjoy seeing what grows up when I don't lay down a harsh control layer. Which means that I have to weed things manually if the newcomers aren't bold enough to crowd out the grass. I still haven't eliminated the burdock, because it keeps showing up in areas where I already have things growing that I intend to keep. One of these years, I'll have those deep roots finally tapped out of nutrients as I keep lopping off the leaves.