NasalCrom

[mellowtigger]

I've been using NasalCrom for several months, and it's an amazing drug. I've had severe allergies my entire life, and I'm certain they played a part in the 2 sinus surgeries that I've already had, thanks to sinus polyps that my overactive sinuses eventually generate which leads to blocked airways and high fevers due to infection. The allergies and the associated sinus troubles are not a real concern any more, thanks to Nasalcrom.

My thanks to wispywillow for mentioning it last summer. In searching for that post, I see that furr_a_bruin mentioned it back in 2011 too, although apparently I never gave it a proper try back then. That's a shame, because it works wonders.

I still can't figure out how it works. It's not a histamine/anti-histamine kind of drug. It's a mast cell stabilizer drug. I don't know much about MCAS (mast cell activation syndrome), but it's related to that. The best analogy I can find is that NasalCrom orders these cells to "Calm down!", so they don't respond with histamine reactions when your immune system tells them that you are exposed to allergens. So, you're still allergic to stuff, but... nothing happens.

That's my experience too. Taking only NasalCrom and nothing else, I can still develop an itchy nose plus a few sneezes. What changes, though, is that my sinuses fail to explode with mucus production. I also take generic fluticasone propionate (sometimes known as Flonase), which is a steroid to reduce inflammation. It's a drug commonly used to deal with asthma, allergies, and nasal polyps like I have a long history of developing. Together, I can even leave my window open at night if I want to, and I don't have to regret it in the morning. At most, I can sometimes tell that my sinuses might be ever-so-slightly swollen or sensitive, like they're on alert because they know allergens are present, but there are no debilitating symptoms that go with it. NasalCrom does the heavy lifting, while the fluticasone softens the few remaining issues.

Together, I'm hopeful that I won't have to deal with polyps blocking my sinuses due to overactive tissues reacting to airborne allergens. If I have no more polyps, then I have no recurring sinus blockage and raging high temperatures, and with no dangerous high temps over 39.5C/103.1F, then I'll have no need for a 3rd sinus surgery. It's a wonder drug, targeted specifically at my sinus tissue. I'm certain it's better for my body than eating pills that affect my whole body, just so I can survive another few hours with strong symptoms.

Comments

[rebeccmeister]

That is so great to hear about! I can’t claim to know anything about immunology, but this sounds like one of the sorts of drug innovations made possible by all the technological innovations associated with gene and gene transcript and protein sequencing. My guess is that mast cells escalate the local response, so that’s what’s getting shut down.

But every immunology talk I’ve ever gone to has involved a billion signaling cascades and different cell types, so clearly, it’s complicated and we just have to be grateful to all the scientists immersed in immune research. (And we need to keep yelling at politicians to get back to funding research!)

[darkoshi]

That is wonderful. I had not heard of that medication.