mellowtigger: (dna mouse)
[personal profile] mellowtigger
Most people know that they get half of their dna from their mother and half from their father. What most people don't know, however, is that they also inherit another kind of dna exclusively from their mother. The mother provides the "egg", and the egg is very special. It includes extra material that every cell needs to survive and replicate. One vital feature inside our cells is the mitochondrion, a small factory that produces the chemical energy that we need to thrive. Mitochondria have their own dna, separate from our regular dna, and we inherit it entirely from the egg.

Without mitochondria, we would slowly die. Our cells individually would simply run out of fuel to function. I kept up with news in the early 1990s about medical trials because I knew college students who participated in this "job" sector as volunteer medical test subjects. I remember that one study was terminated prematurely because its participants died. They discovered that the drug was destroying human mitochondrial dna (although it did not harm dogs in previous tests), so their test volunteers were slowly starving to death, cell by cell, throughout their bodies. The point being that the health of our mitochondria affects our bodies profoundly, so our maternal heritage of mitochondrial dna is an important part of our genetic lineage.

One side-effect of these powerhouses doing their normal function is the production of hydrogen peroxide, H2O2. As any child who's seen hydrogen peroxide bubble on their wounds would know, this chemical is highly reactive. Since mitochondria produce it, our cells need a way to harness the chemical before it reacts with other chemicals in our cells (like our dna) and causes harm. This destructive reaction by oxygen-containing molecules or free radicals is known in a very generic way as "oxidative stress". We need antioxidants to defend against that damage.

Oxidative stress is now linked to a great many disorders, from Parkinson's to Autism and more. Of particular interest to me is the realization that it can trigger mitochondrial dysfunction in some people with autism, separate from the known long-term dysfunction comorbidity. Mitochondrial dysfunction would leave me feeling tired, unfocused, and thoroughly exhausted by physical activity... which matches nicely with my symptoms.  We've ruled out multiple sclerosis to explain my own health problems, so I've separated the symptoms of muscle twitches/cramps (which is responding very positively to a gluten-free diet) from the symptoms of exhaustion, brain fog, and apparent dopamine depletion. I am considering oxidative stress as an explanation for this second set of symptoms which has not responded to Ropinarole.

I've spent a lot of money on medical bills this year. Now that I'm earning a poor person's wages again, I have to get my spending under control. There are expensive tests for objectively measuring mitochondrial dysfunction, but doctor visits will have to wait while I slowly accumulate more discretionary funds. Instead, I'm experimenting more cheaply by taking supplements that affect mitochondrial function and oxidative stress. Most diet supplement pills are known to be ineffective, so I'm trying to stick with ones already proven to have some effect in reputable journals.

I bought some pills containing:
  • glutathione,
  • coenzyme Q-10,
  • vitamin E, and
  • selenium.
I can get more vitamin C and beta-carotene just by eating some carrots. I'll try adding plenty of turmeric spice to my meals too. I hope this combination will improve my energy level, memory/concentration, and dopamine. In theory, it should; but in practice, we'll see.
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